Barry Allen is the fastest man alive. Using his super-speed powers, he taps into the Speed Force and becomes a costumed crime-fighter.
Wally West is the son of Joe and the late Francine West, and the younger brother of Iris West. He later regained his speed in the post-Flashpoint timeline, donning the name Kid Flash
Iris West is a journalist working for the Central City Picture News, Iris is also the daughter of Joe and and the older sister of Wally West,
Reverse Flash was a meta-human speedster from the 22nd century, a descendant of Eddie Thawne, a time criminal, and the archenemy of Barry Allen/The Flash
Francisco "Cisco" Ramon, nicknamed Vibe by Barry Allen, is a mechanical engineering genius and a meta-human at S.T.A.R. Labs, also formerly serving as the prison guard to their makeshift prison.
Killer Frost's ability to figuratively and literally chill anyone to the bone and her wanton disregard of life make her an incredibly dangerous foe one who not only wants to kill but also takes pleasure in doing so.